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KMID : 0613820120220101339
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Journal of Life Science
2012 Volume.22 No. 10 p.1339 ~ p.1343
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Inhibitory Effect of PG-Platycodin D on the Development of Atopic Dermatitis-Like Skin Lesions in ICR Mice
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Park Sae-Jin
Kim Yoon-Suk
Kim Tack-Joong
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Abstract
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Atopic dermatitis is characterized by chronically pruritic and inflammatory dermatitis. In this study, we investigated the effect of Platycodon grandiflorum including platycodin D (PG-Platycodin D) in an atopic dermatitis-like mouse model. An atopic dermatitis-like skin lesion was induced by repeated treatment of 2,4-dinitrochlorobenzene (DNCB) on the dorsal skin of ICR mice. The efficacy of PG-Platycodin D was tested by observing scratching behavior, the skin severity score, and histopathologic analysis. PG-Platycodin D reduced the DNCB-induced increase in scratching behavior and the skin severity score. In addition, histopathologic analysis revealed a reduction in the thickening of the epidermis in the PG-Platycodin D group. These results may contribute to the development of a therapeutic drug for the treatment of atopic dermatitis.
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KEYWORD
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Atopic dermatitis, PG-playticodin D, severity score, scratching behavior
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